Organisation/Company CNRS Department Plasticité du cerveau Research Field Neurosciences Biological sciences Researcher Profile Recognised Researcher (R2) Application Deadline 11 Nov 2026 - 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Jan 2027 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Offer Description
Effects of artificial KCC2 clustering on intracellular chloride regulation in hippocampal interneurons and pyramidal cells, and on epileptic activity
We will develop super-resolution imaging and single-molecule tracking of KCC2 in interneurons and pyramidal cells in mouse hippocampal slices or human epileptic tissue.
After characterizing and comparing the membrane distribution and mobility of KCC2 in interneurons and pyramidal cells, we will determine the impact of antibody-induced artificial KCC2 clustering.
We will then investigate the functional impact of this strategy using electrophysiology (patch-clamp recordings of EGABA and multielectrode array (MEA) recordings of network activity) in human epileptic tissue slices.
The successful candidate will join the La Synapse Dynamique team, led by Sabine Lévi and based in the Brain Plasticity Unit (UMR 8239) at ESPCI Paris. Our research focuses on the cellular and molecular mechanisms underlying the stabilization of nascent synapses during development and the plasticity of mature synapses, with a particular emphasis on hippocampal GABAergic synapses. We use single-molecule imaging techniques, including single-molecule tracking in live neurons and super-resolution STORM/PALM microscopy.
- Neurosciences
- Electrophysiology and super-resolution imaging
- Autonomy
- Ability to work effectively as part of a team
- Ability to regularly report results and progress to the line manager
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Post doctoral position (M/F) employeur : CNRS
Rejoindre la Délégation régionale Bretagne et Pays de la Loire du CNRS, c'est intégrer une équipe RH dynamique et engagée, dédiée à l'accompagnement des laboratoires de recherche. Vous bénéficierez d'un environnement de travail collaboratif, riche en opportunités de développement professionnel, tout en profitant d'avantages tels que 44 jours de congés annuels et une prise en charge significative des frais de transport. Ici, l'autonomie et la proximité avec le terrain sont valorisées, vous permettant de contribuer activement à des projets RH structurants au service de la recherche publique.
