Post-doctoral position in Chemical/biology (M/F)

Organisation/Company CNRS Department Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques Research Field Chemistry Biological sciences Pharmacological sciences Researcher Profile First Stage Researcher (R1) Application Deadline 11 Nov 2026 - 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 4 Jan 2027 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

This project will focus on m6A RNA modification with the objective to explore new RNA modifications to further enhance mRNA vaccine performance.
The post-doctoral position will be divided in three objectives:

• 1-Develop original chemo-enzymatic methods for site-specific RNA modifications, based on chemoenzymatic strategies and Induced Chemical Proximity (ICP) .
• 2-Gain deeper insights into the impact of RNA modifications on mRNA-based therapeutics.
• 3-Apply these methods to the modification of mRNA vaccines.

RNA chemistry

The candidate with a PhD in organic chemistry should have strong background in organic synthesis, characterization methods (NMR 1D, 2D, and MS) and purification techniques (column chromatography, HPLC). An experience in nucleosides and nucleotides chemistry would be appreciated. The expected qualities of the candidate are a high motivation for research at the interface of chemistry and biology, independency in research work, as well as good written and oral communication skills.

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