Research Team: Chemistry of RNAs, Nucleosides, Peptides and Heterocycles
Research Areas: Organic Chemistry | Medicinal Chemistry | β-Lactamase Inhibitors | Antibiotic Resistance | Chemical Biology | Drug Discovery | Synthetic Chemistry
The Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (LCBPT), UMR8601 at Université Paris Cité is seeking a motivated Postdoctoral Researcher to work within the Chemistry of RNAs, Nucleosides, Peptides and Heterocycles team led by Laura Iannazzo.
The project focuses on developing new β-lactamase inhibitors and β-lactams to address antibiotic resistance, particularly resistance driven by Klebsiella pneumoniae carbapenemase (KPC) enzymes.
What You’ll Work On
Antibiotic Resistance & β-Lactamase Research
The project addresses the growing public-health challenge of antimicrobial resistance (AMR), with a particular focus on bacterial resistance mechanisms involving β-lactamases.
The research will investigate strategies for developing chemical compounds capable of targeting β-lactamase-mediated antibiotic resistance.
A major focus will be on Klebsiella pneumoniae carbapenemases (KPCs), which are important β-lactamase enzymes associated with resistance to carbapenem antibiotics.
The selected postdoctoral researcher will contribute to the development of new chemical entities through synthetic organic and medicinal chemistry approaches.
Research activities will include:
- Development of synthetic strategies
- Synthesis of β-lactamase inhibitors
- Synthesis of β-lactam compounds
- Expansion of chemical diversity
- Structure-based compound development
- Chemical optimization of potential inhibitors
- Investigation of structure–activity relationships
The project aims to expand the chemical diversity of β-lactamase inhibitors and β-lactams with potential applications in combating antibiotic resistance.
KPC Mutational Landscape & Resistance Mechanisms
The research will be conducted in collaboration with a broader consortium bringing together expertise in antimicrobial resistance, structural biology, and computational approaches.
The project will investigate the mutational landscape of KPC enzymes to better understand how evolutionary changes influence enzyme activity and resistance.
Research will integrate:
- KPC enzyme mutational analysis
- Evolutionary constraints
- Structure–activity relationships
- Protein–ligand interactions
This integrated approach will support the identification of β-lactamase inhibitors and β-lactams that can exploit evolutionary constraints of the enzyme and potentially limit the emergence of resistance.
The project is part of a multidisciplinary consortium involving expertise in:
- Antimicrobial resistance
- Organic chemistry
- Medicinal chemistry
- X-ray structural analysis
- Computational modeling
- Chemical biology
The selected researcher will work within an interdisciplinary research environment connecting chemistry and biology.
Applicants should have:
- Strong knowledge of organic chemistry.
- Strong knowledge of medicinal chemistry.
- Experience or strong interest in synthetic chemistry.
- An interest in the interface between chemistry and biology.
- Motivation to work on problems related to antimicrobial resistance.
- Ability to work in an interdisciplinary research environment.
Candidates interested in applying chemical approaches to biologically relevant problems are particularly suited to the project.
Desirable Research Background
Experience or knowledge in one or more of the following areas would be relevant:
- Organic synthesis
- Medicinal chemistry
- Synthetic methodology
- Antibiotic resistance
- Chemical biology
- Structure–activity relationship studies
- Protein–ligand interactions
- Computational chemistry
- Structural biology
What You’ll Gain
- Experience in organic and medicinal chemistry research.
- Research experience addressing antibiotic resistance.
- Experience developing new β-lactam-related chemical entities.
- Exposure to interdisciplinary chemistry–biology research.
- Collaboration with researchers working in antimicrobial resistance.
- Opportunities to work alongside structural and computational research approaches.
- Experience investigating enzyme evolution and resistance mechanisms.
- Development of advanced synthetic chemistry skills.
Position: Postdoctoral Researcher
Research Unit: UMR8601
Research Team: Chemistry of RNAs, Nucleosides, Peptides and Heterocycles
Location: Center of Paris, France
Contract Duration: 12 Months
Expected Start: Between January and March 2027
Research Area: Organic & Medicinal Chemistry
The project focuses on developing chemical strategies to address bacterial antibiotic resistance, particularly resistance associated with β-lactamase enzymes.
The research will focus on:
- Antibiotic resistance
- Synthetic organic chemistry
- Medicinal chemistry
- Chemical diversity
- Mutational landscapes
- Enzyme evolutionary constraints
- Chemistry–biology interface
The project aims to identify compounds that can target β-lactamase activity while taking into account the evolutionary constraints governing enzyme resistance.
The position is based at Université Paris Cité, within the LCBPT (UMR8601) in central Paris.
The researcher will join the Chemistry of RNAs, Nucleosides, Peptides and Heterocycles team and participate in a multidisciplinary consortium combining:
- Organic chemistry
- Medicinal chemistry
- Antimicrobial resistance research
- Computational modeling
- Chemical biology
This environment provides an opportunity to work at the intersection of synthetic chemistry, molecular biology, and antimicrobial drug discovery.
Applicants should highlight their relevant background in organic and medicinal chemistry, synthetic research experience, and interest in chemistry–biology research.
Laboratory: LCBPT – UMR8601
Research Team: Chemistry of RNAs, Nucleosides, Peptides and Heterocycles
Position: Postdoctoral Researcher
Research Area: Organic & Medicinal Chemistry
Key Research Areas: Synthetic Chemistry | Medicinal Chemistry | Chemical Biology | Antimicrobial Resistance
#PostdocPosition #PostdoctoralResearcher #OrganicChemistry #MedicinalChemistry #SyntheticChemistry #ChemicalBiology #AntibioticResistance #BetaLactamase
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Postdoctoral Position in Organic & Medicinal Chemistry | Université Paris Cité employeur : Biopractify
L'Institut Pasteur est un employeur de choix, offrant un environnement de recherche interdisciplinaire de premier plan à Paris. En tant que chercheur postdoctoral, vous bénéficierez d'opportunités de collaboration internationale avec des équipes de la Technical University of Munich et de Monash University, tout en développant vos compétences en microbiologie, spectrométrie de masse et modèles organoïdes. La culture de travail valorise l'innovation et le partage des connaissances, vous permettant de contribuer à des recherches fondamentales sur les interactions hôte-microbe et la biologie des parois cellulaires bactériennes.
